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A 0.01% label does not make trials interchangeable

TrialWhat was comparedReported result and limit
LAMP · Hong Kong · 2019438 children aged 4–12; three concentrations and placebo; 1 yearConcentration-related differences in group outcomes. The reported values are specific to this trial.
PEDIG · U.S. · 2023187 children aged 5–12; 0.01% and placebo; 2 yearsNo slowing of refractive progression or axial elongation detected.
CHAMP-UK · 2026289 children aged 6–12; preserved 0.01% and placebo; 2 yearsDifferences favored atropine: 0.33 D (95% CI 0.17–0.49) and 0.14 mm (0.07–0.21).
Different products, participants and methods can contribute to different results. This board does not establish the cause of the difference or provide a prescribing rule. Sources: [1] [2] [3] ·

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